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The control group was set to receive varenicline, while the genetic group would start treatment with varenicline or bupropion (for CHRNA4 rs1044396 (genotype CT or TT) or CYP2B6 rs2279343 (genotype AA), respectively)

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Smoking increases the mutation burden across multiple cancer types, with specific signatures linked to direct exposure to tobacco carcinogens like benzo[a]pyrene

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