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Researchers recruited 338 adults who had a BMI over 30 or a BMI of 2730 with one or more weight-related conditions and were assigned to one of the following experimental groups or a placebo group: 1 mg of subcutaneous retatrutide 4 mg of subcutaneous retatrutide, starting at an initial dose of 2 mg 4 mg of subcutaneous retatrutide, starting at an initial dose of 4 mg 8 mg of subcutaneous retatrutide, starting at an initial dose of 2 mg 8 mg of subcutaneous retatrutide, starting at an initial dose of 4 mg 12 mg of subcutaneous retatrutide, starting at an initial dose of 2 mg The trials promising results pave the way for further phase 3 research to evaluate retatrutides efficacy in comprehensive obesity management and its impact on associated health issues

Sigel A, Sigel H, Sigel R

GPR119, a major enteroendocrine sensor of dietary triglyceride metabolites coacting in synergy with FFA1 (GPR40)