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In addition, to facilitate regulatory acceptance, applicants should clearly describe their NAM, including the context in which the NAM will be used (e.g., for screening/prioritization or quantitative risk assessment), the relevance of the model system to human biology and mechanisms of toxicity, and how the NAM informs the toxicological issue/gap

Some of them are chemically similar to substances known to trigger asthma through hypersensitivity reactions and may pose significant health risks

Secondhand smoke can make children suffer serious health effects

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A Systematic Review of the Effects of Price on the Smoking Behaviour of Young People (Centre for Reviews and Dissemination, 2009)