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Because take-up rates are so low, and there is robust evidence they increase the probability of smoking cessation in RCTs, increasing the use of medications like varenicline could be a cost-effective intervention

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Airway irritation and cough evoked by inhaled cigarette smoke: role of neuronal nicotinic acetylcholine receptors

Building on this understanding, we then assemble a validated mathematical and computational model for linkage of existing experiment data, and interrogate the model to reveal novel connections between underlying mechanisms (Figure 1)