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Mulroney TE, Pyry T, Yam-Puc JC, Rust M, Harvey RF, Kalmar L, et al

Patients often present with fatigue, glossitis, and neurologic symptoms

however, in participants undergoing heavy physical stress (e.g., marathon runners, skiers, or soldiers in subarctic conditions), vitamin C supplementation halved the incidence of colds (5 trials)

Localized histamine responses can occur even with highly purified materials

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