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In contrast, a decreased metabolism would be expected to allow for prolonged drug effectiveness and/or to increase the likelihood of off-target adverse effects with increased side-effects due to accumulation of the drug compound

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Methods: This study included 49,320 individuals who had received health examinations provided by the Korea National Health Insurance Service

PROSPECTIVE STUDY A clinical study in which the analysis of the outcome was based on the data that were collected after the completion of a pre-designed study