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Tobacco cigarettes contain nicotine, a highly addictive substance that leads to long-term dependency and health issues like lung cancer, heart disease, and respiratory problems

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Risks need to be better communicated Several large studies have described the links between moderate levels of alcohol and breast cancer

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Especially because regulators may not be as familiar with NAM data, it is essential for the regulated community to provide scientific justification for using NAM data in lieu of vertebrate animal data in a regulatory filing