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Louisville's tobacco warehouses, auction houses, and manufacturing facilities were economic anchors for the region across much of the twentieth century, and Brown and Williamson's presence there, particularly after the 1929 relocation of its main operations, made the company one of the city's defining employers and institutions

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The large oxidative burden, caused by mitochondrial dysfunction, has been confirmed to be the principal cause of abnormal response and refractory inflammation due to exposure to CS (Jiang et al., 2017)

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Conclusion It is likely that deleterious oral health effects vary between ENDS products