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Each stage has distinct clinical features and degrees of infectivity

More than one in fifty 15-year-olds in England smoke more than once a week (2.2%).[7] See also ASH Fact Sheet: Smoking statistics ASH Key Topic: Youth smoking ASH Fact Sheet: Young people and smoking Secondhand smoke Exposure to other peoples smoke increases the risk of lung cancer in non-smokers by 20-30% and coronary heart disease by 25-35%.[8] It is especially harmful to babies and children

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We are proposing several candidate pathogenetic mechanisms, which all converge on the pulmonary DCs and interact within the complex cellular and molecular environment which is the lung (Figure 4)