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Some of the most common allergens causing eye allergies in dogs include: Tree and grass pollen Mold and mildew Dust and dust mites Fleas Dander, hair, and feathers Cigarette smoke Dog foods or specific ingredients (including meats, grains, soy, etc.) Medications like flea treatments or insecticidal shampoos Household cleaning products Colognes and perfumes Certain fabrics and materials The number of allergens that can cause an allergic reaction in a dog are so wide-ranging and individual to every dog that it's usually difficult to pinpoint the source of the problem by yourself without proper testing