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First, the bias covariates used, although carefully extracted and evaluated, were based on observable study characteristics and thus may not fully capture unobserved characteristics such as study quality or context, which might be major sources of bias

In the end, you're just all alone. Ignacio Labayen de Inza, the founder of the harm reduction group Controlling Chemsex, said that heightened levels of isolation could be dangerous for meth users

Plaque, which causes a variety of issues, will damage your gums if it has grown below the gumline

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Smoking can also result in gum disease, premature tooth loss, discolouration of teeth, etc