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NNN and NNK primarily form during the curing process for tobacco, where the leaves are dried through contact with combustion gases from heat (flue) curing or microbial activity in air curing

The level of nicotine in the blood depends on the amount of nicotine in the smokeless tobacco product, the tobacco cut size, the products pH (a measure of its acidity or basicity), and other factors

Many long-term studies report increasing RRs over time 7,8,9,10 , however, the possible plateauing recently in our New Zealand study appears to be novel

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Smoking remains a major public-health burden in Vietnam, linked to more than 14 percent of all deaths in 2021