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Both smoking and HPV are associated with heightened oxidative stress and DNA damage, which are factors in cancer and, according to previous research, can regulate superoxide dismutase 2 [ SOD2 ], a putative biomarker of oral cancer malignancy and other diseases associated with HPV. The researchers first conducted in vitro experiments to analyze oral cells that expressed the oncoproteins HPV16 E6 and E7 [ showing infection by HPV ] and were exposed to cigarette smoke condensate

New York Post, 2024