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Westrick, N

Vleminckx S, Virgilio N, Asserin J, Prawitt J, Silva CIF

Metformin directly acts on mitochondria to alter cellular bioenergetics

As an important component of regulating metabolism and immune homeostasis, the vagus nerve can regulate WAT content through the central nervous system to control sympathetic peripheral muscle bundles, and can also regulate the release of GSH and NO to enhance antioxidant capacity and prevent ferroptosis (103)