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Lin W, Muscat JE

In 1906 with the development of safe flint material, the production of a practical small size lighter would be possible

When the mice were fed a diet deficient in choline, that is, lacking precursors required for DMG production, they failed to gain weight after smoking cessation. The second bioactive metabolite, acetylglycine, or ACG, followed a mirror-image pattern to that of DMG: Its levels were reduced during active exposure to smoke and after the exposure stopped, they increased following antibiotic treatment

New Phytol 159(2):431441

Simple aesthetics: No major design overhaul - still looks very utilitarian