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Therapeutic Inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage

Yet, selenium levels were only non-significantly lower in both obese groups

These electrophysiological abnormalities were rescued in iPSC-CMs with either adenoviral expression of WT-TANGO2 or correction of the pathogenic variant using CRISPR editing

The 9 mg and 12 mg doses tested in TRIUMPH-4 are expected to form the therapeutic range, with 2 mg as the starting dose

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