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A new perspective on constipation is provided by our study of serum cotinine levels, which are often used as a means of distinguishing smokers from non-smokers at the cutpoint of 3 ng/mL, and the promoting effect on stool frequency-related constipation may not appear in the general population but may appear when cotinine levels range between 0.05 and 2.99 ng/mL

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If youre a typical road tripper or overlander buying a car plug-in cooler in 2026, start with a 12V/24V thermoelectric unit under 30L capacity unless you need freezer capability or plan extended off-grid use

doi:10.1038/nrc1954