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One fanciful story described how Sir Walter Raleghs servant, seeing him smoking a pipe for the first time, threw a bucket of water on him, assuming that he was on fire

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What does science say

Since hemoglobin has 200 folds greater affinity for CO, carboxy hemoglobin is produced copiously 22 that eventually ruptures the hematoporphyrin from the hemoglobin and flushes into the plasma stream