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PET studies have demonstrated that compared to healthy controls, antipsychotic-free patients with schizophrenia showed reduced hippocampal binding of an 5-GABA A selective ligand [82], but along with CHR-P individuals [83], show no differences with less specific 1-3,5-GABA A ligands [84,85,86,87]

The researchers said the risk that using cannabis may actually increase drinking is higher for people who tend to combine cannabis and alcohol to enhance the effects of each or if they use the substances together in social settings

Chronic use focuses on the long-term pattern over time

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