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Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation

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Proteins were purified using Ni-NTA resins for immobilized metal affinity chromatography

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12 weeks (2 4 8 mg titration): ~3 vials 24 weeks (up to 12 mg weekly): ~9 vials 48 weeks (maintenance at 12 mg): ~21 vials Insulin Syringes (U-100, 1 mL) Per week: 1 syringe (once-weekly dosing) 12 weeks: 12 syringes 24 weeks: 24 syringes 48 weeks: 48 syringes Bacteriostatic Water (10 mL bottles) Use 2.4 mL per vial for reconstitution