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Clin Transl Med

The worlds largest transnational tobacco companies are known as the Big 4, and include Philip Morris International (PMI), British American Tobacco (BAT), Japan Tobacco International (JTI) and Imperial Brands

As a result the industry has looked to evolve and focus on so-called next generation products like e-cigarettes and vaporisers

People who are pregnant or nursing should seek medical advice before using it