cigarette smoking and crohn's disease The impact of tobacco on treatment choice efficacy in inflammatory bowel YMJ :: Yonsei Medical Journal

In smokers volar forearm skin, we found increased epidermal differentiation, which may represent a compensatory mechanism induced as an adaptive response to environmental toxins such as PAHs present in cigarette smoke, or nicotine, both of which have the ability to stimulate keratinocyte differentiation

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You can also develop sinusitis after having a bacterial infection, like strep throat