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People with severe kidney disease require more individualized dosing and monitoring because vitamin handling changes in renal impairment

FTH neuron-specific knockout (FTH-KO) mice are more susceptible to ferroptosis after TBI, and the absence of FTH offsets the protective effect of melatonin on ferroptosis induced by TBI, 659 suggesting that melatonin plays a protective role at least in part by inhibiting FTH-mediated ferroptosis in neurons after TBI

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2018 Sep 10 Hardin JS, Zarate YA, Callewaert B, Phillips PH, Warner DB

Thevis, M