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The price tag was also huge

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The Risk Of Bias In Non-randomized Studies - of Interventions (ROBINS I) tool 8 was used to evaluate the risk of bias in one quasi-experimental design study and in one RCT that did not use randomization for participant assignment to the AC method or control group

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These results demonstrate that low-dose PNE alters the development of the corticosteroid dopamine system in a manner that may underlie clinical deficits seen in adolescents such as increased incidence of substance abuse