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Both intracellular and extracellular events are involved in pathophysiological processes in APAP-induced cytotoxicity, including drug metabolism, mitochondrial oxidative stress, DNA damage and microcirculatory dysfunction

Most peptides are administered as subcutaneous self-injections (similar to GLP-1 medications), with dosing schedules that vary by peptide and goal

A structurally related drug, phenformin, was removed from use in the treatment of diabetes in the US in 1977 due to an increased risk for lactic acidosis

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