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doi:10.1177/00034894211018921

It depends on the cause of the deficiency, ongoing risk factors, and how well the treatment works

Rhonda Patrick: They try to make as much energy

10.1111/j.1365-3040.2011.02400.x Plant Cell Environ

Importantly, nuclear-localized FOXO4-positive Leydig cells in elderly testes showed reduced expression of 3-HSD, a rate-limiting enzyme in testosterone synthesis, implying a connection between nuclear FOXO4 and age-related decline in testosterone production [1]