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The combination of abnormal dopamine neurotransmission and nAChR signaling, along with imbalances in glutamate and GABA transmission, which influences the former dysfunctions, may lead to the widespread deficits and symptoms observed in SZ ( Tobacco Use and Antipsychotic Medication Cigarette smoking has been found to increase activity of the liver enzyme, cytochrome P450 1A2 (CYP 1A2), which in turn break down drugs in the body, including antipsychotic medications such as olanzapine and clozapine (112)

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"There is hope that combining genetic analyses with longitudinal epidemiological study designs will help untangle some of these issues," says Professor Michael Owen, Director of the Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University