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It has also been shown that the hypoxanthine-guanine phosphoribosyltransferase (HGPRT) gene in smokers has a higher frequency of reversal and a lower frequency of conversion compared to the corresponding gene in non-smokers, suggesting that cigarette smoke may induce adducts at guanine bases in the non-transcribed DNA strand, leading to an increased frequency of HGPRT gene mutations in smokers 26 and that frequent HGPRT gene mutations in smokers may lead to decreased enzyme activity, resulting in increased hypoxanthine and guanine levels and thus increased blood uric acid levels 27

We generated a total of 300 representative samples coming from three barangays (the basic political unit in the Philippines) of selected cities or municipalities of regional strata

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This ensures any air leaks in the room will flow from outside the room to the inside