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(Smoking and Health, 1964) The report found that smoking is a cause of lung cancer and laryngeal cancer in men, a probable cause of lung cancer in women, the most important cause of chronic bronchitis and a contributing factor to cardiovascular diseases, resulting in a higher death rate from coronary artery disease among male cigarette smokers

Nonetheless, the same questionnaire was used in a series of cross-sectional studies, which can provide evidence of trends in e-cigarette use among this population

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Furthermore, early exposure to nicotine increases the likelihood of developing other addictions later in life, as it primes the brain for addictive behaviors, making young users more vulnerable to substance abuse

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