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Reducing smoking-related harm at the population level depends not only on the potential reduction in risk to the individual who switches from cigarettes to the smoke-free product, but also its adoption by adult smokers

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Imperial Brands is set to launch its travel-exclusive ultra-premium tobacco range, Davidoff Selected Leaf, as it returns to the TFWA World Exhibition in Cannes (Golden Village GO6)

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Acknowledgements We thank our subjects and the staff of GE Imanet for their assistance with the positron emission tomography scans, in particular Ms Hope McDevitt, Mr Andrew Blyth, Ms Andreanna Williams, and Ms Stephanie McKnight