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In 2019, some 5 million middle- and high-school students reported having used e-cigarettes in a recent 30-day period, an increase from 3.6 million the year before, according to the National Youth Tobacco Survey released by the federal Centers for Disease Control and Prevention

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However, an American Thoracic Society (ATS) systematic review of eight studies demonstrated that extended use of a controller therapy for greater than 12 weeks leads to significantly higher sustained quit rates and lower relapse rates compared with standard use of six to 12 weeks, with a number needed to treat (NNT) of 19 for one additional patient achieving abstinence at one year