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After passing through 0.45 m membrane filters, 2 cc of the sample was added to a dedicated vial and placed in a preheated digester (150 C) for 2 h

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Among the studies that do analyze doseresponse relationships, there is large variation in the units and dose categories used in reporting their findings (for example, the use of pack-years or cigarettes per day) 24,25 , which complicates the comparability and consolidation of evidence