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This proposed lineage relationship between tuft-like cells, ionocytes, and PNECs may relate to our observation of an age-dependent balance of rare cell ratios and the recently reported tuft-like variants of small cell lung cancer, generally thought to be a PNEC-derived tumor 58

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Although cigarette smoking prevalence has generally declined over the past several decades, results from the 2017 National Health Interview Survey indicate that approximately 34.3 million U.S

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