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The nicotine patch will be dispensed weekly during this titration phase, with dose adjustments made by the study physician at each weekly study visit based on tolerability and the average number of cigarettes smoked per day (CPD) in the preceding week (see Table 1 for the dosing algorithm based on amount of continued smoking)

Proceedings of the National Academy of Sciences of the United States of America, 118 (40), e2015867118

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