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doi: 10.1016/S0140-6736(19)32517-6 Summary Keywords non-alcoholic steatohepatitis, nonalcoholic fatty liver disease, obesity, insulin resistance, metabolic syndrome, metabolic disease, fibroblast growth factor 21 Citation Tillman EJ and Rolph T (2020) FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases

Second, restricts distribution and is subject to active efflux, yielding heterogeneous brain exposure across regions and patients

Lv, X.-C., Guo, W.-L., Li, L., Yu, X.-D

Slower escalation with better tolerance produces better long-term adherence and results than aggressive dosing that causes misery