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In patients with fatty liver disease, increased ER stress activates UPR through transducers inositol-requiring enzyme 1, protein kinase R-like kinase, and activating transcription factor 6, which promotes the expression of p53, release of cytochrome C from the mitochondria, and the activation of NF-B, JNK, and CEBP signaling pathways in KCs, resulting in IR and apoptosis (159, 160)

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Hosseini MS, Samsampour D, Ebrahimi M, Abada J, Khanahmadi M (2018) Effect of drought stress on growth parameters, osmolyte contents, antioxidant enzymes and glycyrrhizin synthesis in licorice ( Glycyrrhiza glabra L.) grown in the field