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The chronic pain problem: where the evidence and the biology diverge The most common leap I see is the leap from maybe helpful for an acute tendon injury to maybe helpful for arthritis, chronic knee pain, or long-standing degenerative issues. This is where I think the case is weak

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Spinal cord injury generally involves the preclusion of neural relays across the lesion site and is thereby predictably associated with a lack of functional improvement [12, 13]

Practice Bulletin, 196, 1-18