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For adolescents and adults who require inpatient rehabilitationas many as 60% may have a prior history of substance use disorder

Extracted datasets were cross-verified to ensure accuracy

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The evaluation of evidence in this research exposed limitations, especially in the randomized controlled trials that assessed the effects of e-cigarettes

Next, we normalized each participants brain into MNI space with the normalized images modulated to make sure that relative GM volumes were maintained following spatial normalization