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The accumulation of copper catalyzes excessive ROS production, which directly damages mitochondrial integrity and function and activates pro-fibrotic signaling pathwaysmost notably transforming growth factor-beta (TGF-) [37]

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Synergistic Mechanisms in Cellular Assays While each individual peptide possesses distinctly powerful independent mechanisms, contemporary osteoarticular and tissue remodeling studies frequently pair them to document their amplified, overlapping synergistic effects

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