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Key to this approach are (i) the use of agreed reference products for comparison, ideally authorized MRTPs, and (ii) bridging methodologies that allow to compare a cMRTP with the reference products based on a limited number of studies (see challenge 4)

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Inheriting A Fortune Duke's early inheritance included substantial cash holdings, energy and tobacco investments, and multiple large estates, including properties in New Jersey, Hawaii, Rhode Island, and Beverly Hills

On its website, the FDA writes that "it's possible" synthetic nicotine "would not be regulated"

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