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Incidence of total knee arthroplasty after arthroscopic surgery for knee osteoarthritis: a secondary analysis of a randomized clinical trial

Statements Author contributions L-yS: Data curation, Conceptualization, Writing review & editing, Writing original draft, Formal analysis

The angiotensin IV analog Nle-Tyr-Leu--(CH2-NH2)3-4-His-Pro-Phe (Norleual) can act as a hepatocyte growth factor/c-Met inhibitor

Collectively, these findings highlight autophagy as a key mechanism by which NAD + exerts hepatoprotective effects, thereby linking upstream metabolic imbalance to downstream pathological outcomes

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