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n some embodiments, the auris-acceptable penetration enhancer is a surfactant comprising -D-glucopyranosyl--glycopyranoside, n-Dodecyl-4-O--D-glucopyranosyl--glycopyranoside, and/or n-tetradecyl--O--D-glucopyranosyl--glycopyranoside

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For instance, medications that modulate the gut microbiome, such as antibiotics, have been shown to improve some gastrointestinal symptoms associated with ME/CFS, thereby enhancing overall patient well-being [5, 10, 12, 32, 161]