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SantamaraEAvilaMALatasaMURubioAMartn-DuceALuSCet alFunctional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine

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To investigate the severe liver damage and increased mortality observed in hepsin / mice during the early stages after APAP administration, we employed ultra-performance liquid chromatography-tandem mass spectrometry to measure levels of APAP-cysteine adducts in mouse liver tissue, which indirectly assesses the generation of the toxic APAP metabolite, NAPQI (Hairin et al

doi: 10.1016/s0009-8981(03)00200-6