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Journal of Lipid Research, 50 (9), 17211734

Thats clarified a few things

Synthetic Cyanocobalamin for Reliable Supplementation The active ingredient, cyanocobalamin, is a laboratory-produced form of vitamin B12 that works in the body the same way as naturally occurring vitamin B12 found in fish, seafood, dairy products, and egg yolk

When the solution thaws, the peptide doesn't return to its original conformationcopper binding sites may be irreversibly altered

As shown in Figure 7 , in mock- and GSTP1 -transfected HepG2 cells dose- and time- dependent up-regulations of CHOP-GFP signal were detected following treatment with AQ-QI or DEAQ-QI