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Microsphere-based gradient implants for osteochondral regeneration: a long-term study in sheep

Damage to the tight endothelial junctions results in increased BBB permeability, leading to the entry of immune cells and inflammatory cytokines into the parenchyma, as well as impaired clearance of metabolic waste and neurotoxic compounds (Zlokovic, 2004

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10.1038/ajg.2012.255 Am