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Subjects that smoked higher numbers of cigarettes exhibited greater decreases in hippocampal volume, and relatively higher memory scores (although memory was still generally poorer than in all other groups)

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Researchers analyzed chemical residues inside a dozen smoking pipes and pipe fragments collected from archaeological sites along the lower Snake and Columbia rivers

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Taken together, these results indicate that the effect of acute nicotine pretreatment on diazepam-induced GABA network activity in the VTA was mediated by impaired Cl homeostasis and altered GABAergic circuit function