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Since the combination of overexpressing SLC7A11 and SLC3A2 partially alleviated ferroptosis induced by ER knockdown (Figs

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Although a clear mechanistic perspective is lacking, it can be conceptualized that gut microbial dysbiosis (and its metabolites) modulates innate and adaptive immune players by recruiting immune secreting cells from the appendix, thereby priming the immune system for an enhanced inflammatory response and a possible source of -synuclein misfolding (Masahata et al., 2014

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