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III et al

There is good evidence, but not with absolute certainty, that the smoke with the more cancer-causing agents gets deeper to the lungs where adenocarcinomas more commonly occur. Efforts to contact major tobacco companies and industry groups for comment on this study were not successful

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Mitch Zeller, director of the FDAs Center for Tobacco Products, suggested that this round of tobacco regulation would focus primarily on combustible tobacco products, which he called the most dangerous mechanism for the delivery of nicotine