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The brand's journey began in 1924 when Philip Morris Company launched Marlboro in New York, initially targeting women with its characteristic red packaging

It can also lead to a predisposition to addiction, both to nicotine and other substances

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Figure 2 provides a roadmap in which to envision how to optimize ANDS product use to successfully compete with and replace smoking - minimizing risk and making both an individual and a net population health impact

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