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It belongs to alkaloids, with a pyridine cycle and a pyrrolidine cycle, and occupies a higher proportion of ~95% of the total alkaloids in tobacco leaves ( Undoubtedly, smoking increases the risk of many diseases, such as cancer, coronary heart disease, stroke, and chronic obstructive pulmonary disease

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This breathing pattern emphasizes a prolonged exhalation, which stimulates the vagus nervea critical component of the parasympathetic nervous system

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